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https://locus.ufv.br//handle/123456789/29581
Tipo: | Artigo |
Título: | Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
Autor(es): | Rodrigues, Joel Alves Prímola-Gomes, Thales Nicolau Leal, Tiago Ferreira Pedrosa, Danillo Laviola Rezende, Leonardo Mateus Teixeira Natali, Antonio Jose Nóbrega, Clara Oliveira, Edilamar Menezes de |
Abstract: | Regulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups -sedentary hypertensive (SH); trained hypertensive (TH); sedentary normotensive (SN); and trained normotensive (TN). Animals of the TH and TN groups were subjected to treadmill running program, 5 days/week, 1 hour/day at 60-70% of maximum running velocity for 8 weeks. We adopted a p ≤ 0.05 as significance level for all comparisons. Exercise training reduced systolic arterial pressure in hypertensive rats. In normotensive rats, exercise training reduced the time to 50% cell relaxation and the time to peak contraction and increased the time to 50% decay of the intracellular Ca2+ transients. In SHR, exercise increased the amplitude and reduced the time to 50% decay of Ca2+transients. Exercise training increased the expression of miR-214 in hypertensive rats only. The aerobic training applied in this study increased the availability of intracellular Ca2+ and accelerated the sequestration of these ions in left ventricular myocytes of hypertensive rats, despite increased expression of miR-214 and maintenance of cell contractility. |
Palavras-chave: | Hypertension Exercise Rats Calcium signaling Intracellular calcium Sensing Proteins |
Editor: | Arquivos Brasileiros de Cardiologia |
Tipo de Acesso: | Open Access |
URI: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001400172 https://locus.ufv.br//handle/123456789/29581 |
Data do documento: | Ago-2018 |
Aparece nas coleções: | Artigos |
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Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf | Texto completo | 446,82 kB | Adobe PDF | Visualizar/Abrir |
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