Efeitos da aplicação do laser diodo de Arseneto de Gálio (AS-GA) na osteoartrite experimental em coelhos
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Revista Ceres
Abstract
Foram avaliados os efeitos do laser a diodo de Arseneto de Gálio (As-Ga) aplicado no joelho de coelhos portadores de osteoartrite induzida pela aplicação intra-articular de carragenina. A avaliação clínica in vivo demonstrou diminuição dos sinais inflamatórios e da dor, permitindo melhor desempenho e maior amplitude de movimento do joelho dos coelhos tratados, em comparação aos dos animais não tratados. As avaliações macro e microscópica post-mortem evidenciaram processos degenerativos decorrentes da administração de carragenina em ambos os grupos, tratado com laser e não-tratado (controle). Os resultados permitiram inferir que o laser diminuiu os mediadores químicos, reduzindo a resposta inflamatória e lesões locais, inclusive a degradação dos glicosaminoglicanos. A análise histológica da membrana sinovial demonstrou a presence de células inflamatórias, distribuídas difusamente ou em focos, em maior intensidade nos grupos controle. A laserterapia retardou o caráter progressivo da osteoartrite induzida no joelho de coelhos.
The aim of this study was to evaluate the effects of gallium arsenate (Ga-As) diode laser application on rabbits knees with ostheoarthritis induced by intrarticularinjection of carrageenan. Clinical evaluation in vivo showed that there was reduction in inflammatory signs and pain, with treated animals presenting a better performance and greater amplitude of movements, if compared with untreated animals. The degenerative processes resulting from the administration of carrageenan were evidenced in both groups by post mortem gross and microscopic appearance in both treated and control groups, which allowed inferring that laser diminished the presence of chemical mediators, reducing the inflammatory response and local lesions, including the degradation of glycosaminoglycans. Histological analysis of the synovial membrane revealed the presence of inflammatory cells distributed diffusely or in foci, the intensity of which was higher in control groups. The progression rate of induced ostheoarthritis was slowed down by lasertherapy.
The aim of this study was to evaluate the effects of gallium arsenate (Ga-As) diode laser application on rabbits knees with ostheoarthritis induced by intrarticularinjection of carrageenan. Clinical evaluation in vivo showed that there was reduction in inflammatory signs and pain, with treated animals presenting a better performance and greater amplitude of movements, if compared with untreated animals. The degenerative processes resulting from the administration of carrageenan were evidenced in both groups by post mortem gross and microscopic appearance in both treated and control groups, which allowed inferring that laser diminished the presence of chemical mediators, reducing the inflammatory response and local lesions, including the degradation of glycosaminoglycans. Histological analysis of the synovial membrane revealed the presence of inflammatory cells distributed diffusely or in foci, the intensity of which was higher in control groups. The progression rate of induced ostheoarthritis was slowed down by lasertherapy.