Aggregation behavior of self-assembled nanoparticles made from carboxymethyl-hexanoyl chitosan and sodium dodecyl sulphate surfactant in water
dc.contributor.author | Agudelo, Alvaro J. P. | |
dc.contributor.author | Silva, Luis H. M. da | |
dc.contributor.author | Rengifo, Andrés F. C. | |
dc.contributor.author | Santos, Sandra C. | |
dc.contributor.author | Lima, Vania R. de | |
dc.contributor.author | Parize, Alexandre L. | |
dc.contributor.author | Minatti, Edson | |
dc.date.accessioned | 2019-03-11T16:26:39Z | |
dc.date.available | 2019-03-11T16:26:39Z | |
dc.date.issued | 2019-03-15 | |
dc.description.abstract | Biopolymers can be used to produce nano-objects in solution and they are generally of low cost and biocompatible. However, they commonly have low kinetic stability and form aggregates with a broad particle size distribution, characteristics that hinder their use in drug delivery systems. Herein, we report the thermodynamics and mechanisms underlying the formation of nanostructures through the self-assembly of carboxymethyl-hexanoyl chitosan (ONCHC) and the effect of the presence of the surfactant sodium dodecyl sulfate (SDS). The pre- and post-aggregation regimes were monitored using several techniques and indicated that self-assembly is thermodynamically favorable. The presence of SDS decreased the hydrodynamic radius and surface charge of the SDS-ONCHC nanoaggregates and increased the kinetic stability in aqueous solution over a period of 150 days. The SDS-ONCHC interaction is driven mainly by a hydrophobic effect and the addition of SDS increases the number and strength of the hydrophobic domains, where the integral enthalpy change for the aggregate formation is −2.11 kJ mol−1. | en |
dc.format | pt-BR | |
dc.identifier.issn | 0167-7322 | |
dc.identifier.uri | https://doi.org/10.1016/j.molliq.2018.12.125 | |
dc.identifier.uri | http://www.locus.ufv.br/handle/123456789/23846 | |
dc.language.iso | eng | pt-BR |
dc.publisher | Journal of Molecular Liquids | pt-BR |
dc.relation.ispartofseries | Volume 278, Pages 253-261, March 2019 | pt-BR |
dc.rights | Elsevier B. V. | pt-BR |
dc.subject | Carboxymethyl-hexanoyl chitosan | pt-BR |
dc.subject | Polymer surfactant complex | pt-BR |
dc.subject | Isothermal titration calorimetry (ITC) | pt-BR |
dc.subject | Conductivity | pt-BR |
dc.subject | Dynamic light-scattering (DLS) | pt-BR |
dc.subject | Surface tension | pt-BR |
dc.title | Aggregation behavior of self-assembled nanoparticles made from carboxymethyl-hexanoyl chitosan and sodium dodecyl sulphate surfactant in water | en |
dc.type | Artigo | pt-BR |
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