O histórico familiar está associado à presença de dislipidemia em crianças pré‐escolares
Arquivos
Data
2019-01
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Revista Paulista de Pediatria
Resumo
Avaliar a associação entre história familiar e presença de dislipidemias em crianças. Estudo transversal com 257 crianças de 4 a 7 anos de idade do município de Viçosa, Minas Gerais. Foram realizadas avaliações do estado nutricional e do perfil lipídico (colesterol total e frações e triglicerídeos), além do registro de história de dislipidemia dos pais. Para análise estatística, foi utilizado o teste do qui-quadrado de Pearson para identificar associações e teste t de Student para comparação de médias. Foi realizada análise de regressão de Poisson para avaliar a associação independente entre história familiar e a presença de dislipidemia em crianças, sendo adotado o nível de significância estatística de 5%.Crianças com pais dislipidêmicos apresentaram maiores concentrações séricas de colesterol total e triglicerídeos. Na análise de regressão após ajuste, a presença de dislipidemia no pai ou na mãe (RP: 2,43; IC95% 1,12-5,27) bem como a presença de dislipidemia no pai e na mãe (RP: 5,62; IC95% 2,27-13,92) estiveram associadas à hipertrigliceridemia nas crianças. Crianças com pais e mães dislipidêmicos apresentaram maior prevalência de lipoproteína de baixa densidade (LDL-c) elevada (RP: 1,52; IC95% 1,18-1,97).A investigação da história familiar de dislipidemia deve fazer parte de protocolos para verificar a presença de hipertrigliceridemia e dislipidemias na infância.
To evaluate the association between family history and the presence of dyslipidemia in children. A cross‑sectional study with 257 children aged 4 to 7 years old from Viçosa, Minas Gerais, Southeast Brazil. Nutritional status and lipid profile (total cholesterol, cholesterol fractions, and triglyceride) assessments and an active search for a family history of dyslipidemia in parents were carried out. Pearson’s chi‑square test was used to identify associations, and Student’s t‑test was used to compare means. A Poisson regression analysis was performed to assess the independent association between family history and the presence of dyslipidemia in children. A significance level of 5% was adopted. Children of parents with dyslipidemia had higher serum concentrations of total cholesterol and triglycerides. In a regression analysis after adjustments, the presence of dyslipidemia in the father or in the mother (OR: 2.43; 95%CI 1.12–5.27), as well as the presence of dyslipidemia in both the father and the mother (OR: 5.62; 95%CI 2.27–13.92) were associated with hypertriglyceridemia in children. Children of parents with dyslipidemia had a higher prevalence of elevated low‑density lipoproteins (LDL‑c) (OR: 1.52; 95%CI 1.18–1.97). An investigation of the family history of dyslipidemia should be made as part of the protocol to verify the presence of hypertriglyceridemia and dyslipidemia in children.
To evaluate the association between family history and the presence of dyslipidemia in children. A cross‑sectional study with 257 children aged 4 to 7 years old from Viçosa, Minas Gerais, Southeast Brazil. Nutritional status and lipid profile (total cholesterol, cholesterol fractions, and triglyceride) assessments and an active search for a family history of dyslipidemia in parents were carried out. Pearson’s chi‑square test was used to identify associations, and Student’s t‑test was used to compare means. A Poisson regression analysis was performed to assess the independent association between family history and the presence of dyslipidemia in children. A significance level of 5% was adopted. Children of parents with dyslipidemia had higher serum concentrations of total cholesterol and triglycerides. In a regression analysis after adjustments, the presence of dyslipidemia in the father or in the mother (OR: 2.43; 95%CI 1.12–5.27), as well as the presence of dyslipidemia in both the father and the mother (OR: 5.62; 95%CI 2.27–13.92) were associated with hypertriglyceridemia in children. Children of parents with dyslipidemia had a higher prevalence of elevated low‑density lipoproteins (LDL‑c) (OR: 1.52; 95%CI 1.18–1.97). An investigation of the family history of dyslipidemia should be made as part of the protocol to verify the presence of hypertriglyceridemia and dyslipidemia in children.
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Palavras-chave
Child, Parents, Dyslipidemia, Hypertriglyceridemia, Cardiovascular diseases, Criança, Pais, Dislipidemias, Hipertrigliceridemia, Doenças cardiovasculares
