Easy access to evans’ oxazolidinones. Stereoselective synthesis and antibacterial activity of a new 2-oxazolidinone derivative
Arquivos
Data
2014-06-06
Título da Revista
ISSN da Revista
Título de Volume
Editor
Molecules
Resumo
An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.
Descrição
Palavras-chave
Evans’ oxazolidinones, Stereoselective synthesis, Morita-baylis-hillman adduct, Staphylococcus aureus, Mastitis bovina