(Biochemical Systematics and Ecology, 2006-11) Demuner, Antônio J.; Barbosa, Luiz C. A.; Veiga, Thiago A. M.; Barreto, Robert W.; King-Diaz, Beatriz; Lotina-Hennsen, Blas
A phytotoxic compound identified as 6-(3,3-dimethylallyloxy)-4-methoxy-5-methylphthalide (1), was isolated from the phytopathogenic fungus Nimbya alternantherae, cultivated on solid media. Catalytic hydrogenation of 1 resulted in the quantitative formation of second compound (2). Both compounds (1, 2) act by inhibiting the ATP synthesis in spinach thylakoids. A detailed investigation on the mechanism of action indicates that compound 1 acts as a Hill reaction inhibitor and uncoupler of photosynthesis.
