Bioquímica e Biologia Molecular
URI permanente desta comunidadehttps://locus.ufv.br/handle/123456789/11837
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Item Easy access to evans’ oxazolidinones. Stereoselective synthesis and antibacterial activity of a new 2-oxazolidinone derivative(Molecules, 2014-06-06) Diaz, Gaspar; Freitas, Michelle A. A. de; Ricci-Silva, Maria E.; Diaz, Marisa A. N.An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.