Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities of friedelanes from Maytenus robusta branches and isolation of further triterpenoids
dc.contributor.author | Moreira, Maria Eliza C. | |
dc.contributor.author | Sousa, Grasiely F. de | |
dc.contributor.author | Aguilar, Mariana G. de | |
dc.contributor.author | Dias, Danielle F. | |
dc.contributor.author | Takahashi, Jacqueline A. | |
dc.contributor.author | Vieira Filho, Sidney A. | |
dc.contributor.author | Silva, Grácia D.F. | |
dc.contributor.author | Rodrigues, Salomão B.V. | |
dc.contributor.author | Messias, Maria Cristina T. Braga | |
dc.contributor.author | Duarte, Lucienir P. | |
dc.date.accessioned | 2018-08-30T19:36:01Z | |
dc.date.available | 2018-08-30T19:36:01Z | |
dc.date.issued | 2017-09 | |
dc.description.abstract | The new pentacyclic triterpenoids friedel-1-en-3,16-dione (1), 1α,29-dihydroxyfriedelan-3-one (2) and 16β,28,29-trihydroxyfriedelan-3-one (3) were isolated from Maytenus robusta branches in addition to the known, but new for this species, triterpenoid 12α,29-dihydroxyfriedelan-3-one (4). The structures and stereochemistry of the novel triterpenoids were established by IR, 1D/2D NMR and HR-APCIMS spectral data. In addition, the biological activity of compound 2 and the previously isolated friedelanes 5–8 (friedelan-3,16-dione, 29-hydroxyfriedelan-3-one, 29-hydroxyfriedelan-3,16-dione and 16β,29-dihydroxyfriedelan-3-one) was investigated. Compounds 2 and 8 were tested for their acetylcholinesterase properties and antimicrobial activity against the bacteria Staphylococcus aureus, Pseudomonas aeruginosa, Listeria monocytogenes, Citrobacter freundii, and the fungus Candida albicans. Compound 2 was the most active compound for both assays, with values of 32.3% acetylcholinesterase inhibition, 42% activity against the fungus Candida albicans and 34% against the bacterium Pseudomonas aeruginosa. Compounds 5–8 were assayed for their antiedematogenic activity using the carrageenan-induced paw edema assay. At maximum inflammation after three hours, compounds 6 and 8 showed 42% and 57% activity, respectively. After four hours, compounds 5 and 7 showed activity of 71% and 75% compared to 79% of the control indomethacin. | en |
dc.format | pt-BR | |
dc.identifier.issn | 18743900 | |
dc.identifier.uri | https://doi.org/10.1016/j.phytol.2017.05.026 | |
dc.identifier.uri | http://www.locus.ufv.br/handle/123456789/21549 | |
dc.language.iso | eng | pt-BR |
dc.publisher | Phytochemistry Letters | pt-BR |
dc.relation.ispartofseries | v. 21, p. 61- 65, set. 2017 | pt-BR |
dc.rights | Elsevier B.V. | pt-BR |
dc.subject | Maytenus robusta | pt-BR |
dc.subject | Friedel-1-en-3,16-dione | pt-BR |
dc.subject | 1α,29-dihydroxyfriedelan-3-one | pt-BR |
dc.subject | 16β,28,29-trihydroxyfriedelan-3-one | pt-BR |
dc.subject | Anti-inflammatory activity | pt-BR |
dc.title | Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities of friedelanes from Maytenus robusta branches and isolation of further triterpenoids | en |
dc.type | Artigo | pt-BR |
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