Navegando por Autor "Ferreira, Silvio C."
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Item Activation thresholds in epidemic spreading with motile infectious agents on scale-free networks(Chaos: An Interdisciplinary Journal of Nonlinear Science, 2018) Silva, Diogo H.; Ferreira, Silvio C.We investigate a fermionic susceptible-infected-susceptible model with the mobility of infected individuals on uncorrelated scale-free networks with power-law degree distributions P(k)∼k−γP(k)∼k−γ of exponents 2<γ<32<γ<3. Two diffusive processes with diffusion rate DD of an infected vertex are considered. In the standard diffusion, one of the nearest-neighbors is chosen with equal chance, while in the biased diffusion, this choice happens with probability proportional to the neighbor’s degree. A non-monotonic dependence of the epidemic threshold on DD with an optimum diffusion rate D∗D∗, for which the epidemic spreading is more efficient, is found for standard diffusion while monotonic decays are observed in the biased case. The epidemic thresholds go to zero as the network size is increased and the form that this happens depends on the diffusion rule and the degree exponent. We analytically investigated the dynamics using quenched and heterogeneous mean-field theories. The former presents, in general, a better performance for standard and the latter for biased diffusion models, indicating different activation mechanisms of the epidemic phases that are rationalized in terms of hubs or max kk-core subgraphs. Nowadays, we live in an interwoven world where information, goods, and people move through a complex structure with widely diversified types of interactions such as on-line friendship and airport connections. These and many other systems of completely distinct nature can be equally suited in a theoretical representation called complex networks, in which the elements are represented by vertices and the interactions among them by edges connecting these vertices. The study of epidemic processes on complex networks represents one of the cornerstones in modern network science and can aid the prevention (or even stimulation) of disease or misinformation spreading. The relevance of the interplay between diffusion and epidemic spreading in real systems is self-evident since hosts of infectious agents, such as people and mobile devices, are constantly moving, being the carriers that promote the quick transition from a localized outbreak to a large scale epidemic scenario. In this work, we perform a theoretical analysis and report nontrivial roles played by mobility of infected agents on the efficiency of epidemic spreading running on the top of complex networks. We expect that our results will render impacts for forthcoming research related to the area.Item Collective versus hub activation of epidemic phases on networks(Physical Review E., 2016-03-14) Ferreira, Silvio C.; Sander, Renan S.; Pastor-Satorras, RomualdoWe consider a general criterion to discern the nature of the threshold in epidemic models on scale-free (SF) networks. Comparing the epidemic lifespan of the nodes with largest degrees with the infection time between them, we propose a general dual scenario, in which the epidemic transition is either ruled by a hub activation process, leading to a null threshold in the thermodynamic limit, or given by a collective activation process, corresponding to a standard phase transition with a finite threshold. We validate the proposed criterion applying it to different epidemic models, with waning immunity or heterogeneous infection rates in both synthetic and real SF networks. In particular, a waning immunity, irrespective of its strength, leads to collective activation with finite threshold in scale-free networks with large degree exponent, at odds with canonical theoretical approaches.Item Continuous and discontinuous absorbing-state phase transitions on Voronoi-Delaunay random lattices(Physical Review E, 2016-01-11) Oliveira, Marcelo M. de; Alves, Sidiney G.; Ferreira, Silvio C.We study absorbing-state phase transitions (APTs) in two-dimensional Voronoi-Delaunay (VD) random lattices with quenched coordination disorder. Quenched randomness usually changes the criticality and destroys discontinuous transitions in low-dimensional nonequilibrium systems. We performed extensive simulations of the Ziff-Gulari-Barshad model, and verified that the VD disorder does not change the nature of its discontinuous transition. Our results corroborate recent findings of Barghathi and Vojta [H. Barghathi and T. Vojta, Phys. Rev. Lett. 113, 120602 (2014)], stating the irrelevance of topological disorder in a class of random lattices that includes VD, and raise the interesting possibility that disorder in nonequilibrium APT may, under certain conditions, be irrelevant for the phase coexistence. We also verify that the VD disorder is irrelevant for the critical behavior of models belonging to the directed percolation and Manna universality classes.Item Eden model with nonlocal growth rules and kinetic roughening in biological systems(Physical Review, 2018-08) Ferreira, Silvio C.; Santalla, Silvia N.We investigate an off-lattice Eden model where the growth of new cells is performed with a probability dependent on the availability of resources coming externally towards the growing aggregate. The concentration of nutrients necessary for replication is assumed to be proportional to the voids connecting the replicating cells to the outer region, introducing therefore a nonlocal dependence on the replication rule. Our simulations point out that the Kadar–Parisi–Zhang (KPZ) universality class is a transient that can last for long periods in plentiful environments. For conditions of nutrient scarcity, we observe a crossover from regular KPZ to unstable growth, passing by a transient consistent with the quenched KPZ class at the pinning transition. Our analysis sheds light on results reporting on the universality class of kinetic roughening in akin experiments of biological growth.Item Effects of local population structure in a reaction-diffusion model of a contact process on metapopulation networks(Physical Review E, 2013-10-30) Mata, Angélica S.; Ferreira, Silvio C.; Pastor-Satorras, RomualdoWe investigate the effects of local population structure in reaction-diffusion processes representing a contact process (CP) on metapopulations represented as complex networks. Considering a model in which the nodes of a large scale network represent local populations defined in terms of a homogeneous graph, we show by means of extensive numerical simulations that the critical properties of the reaction-diffusion system are independent of the local population structure, even when this one is given by a ordered linear chain. This independence is confirmed by the perfect matching between numerical critical exponents and the results from a heterogeneous mean-field theory suited, in principle, to describe situations of local homogeneous mixing. The analysis of several variations of the reaction-diffusion process allows us to conclude the independence from population structure of the critical properties of CP-like models on metapopulations, and thus of the universality of the reaction-diffusion description of this kind of models.Item Epidemic thresholds of the susceptible-infected-susceptible model on networks: a comparison of numerical and theoretical results(Physical Review E, 2012-10-15) Ferreira, Silvio C.; Castellano, Claudio; Pastor-Satorras, RomualdoRecent work has shown that different theoretical approaches to the dynamics of the susceptible-infected-susceptible (SIS) model for epidemics lead to qualitatively different estimates for the position of the epidemic threshold in networks. Here we present large-scale numerical simulations of the SIS dynamics on various types of networks, allowing the precise determination of the effective threshold for systems of finite size N. We compare quantitatively the numerical thresholds with theoretical predictions of the heterogeneous mean-field theory and of the quenched mean-field theory. We show that the latter is in general more accurate, scaling with N with the correct exponent, but often failing to capture the correct prefactorItem Griffiths effects of the susceptible-infected-susceptible epidemic model on random power-law networks(Physical Review E., 2016-03-28) Cota, Wesley; Ferreira, Silvio C.; Ódor, GézaWe provide numerical evidence for slow dynamics of the susceptible-infected-susceptible model evolving on finite-size random networks with power-law degree distributions. Extensive simulations were done by averaging the activity density over many realizations of networks. We investigated the effects of outliers in both highly fluctuating (natural cutoff) and nonfluctuating (hard cutoff) most connected vertices. Logarithmic and power-law decays in time were found for natural and hard cutoffs, respectively. This happens in extended regions of the control parameter space λ 1 < λ < λ 2 , suggesting Griffiths effects, induced by the topological inhomogeneities. Optimal fluctuation theory considering sample-to-sample fluctuations of the pseudothresholds is presented to explain the observed slow dynamics. A quasistationary analysis shows that response functions remain bounded at λ 2 . We argue these to be signals of a smeared transition. However, in the thermodynamic limit the Griffiths effects loose their relevancy and have a conventional critical point at λ c = 0. Since many real networks are composed by heterogeneous and weakly connected modules, the slow dynamics found in our analysis of independent and finite networks can play an important role for the deeper understanding of such systems.Item Griffiths phases in infinite- dimensional, non- hierarchical modular networks(Scientific Reports, 2018) Cota, Wesley; Ódor, Géza; Ferreira, Silvio C.Griffiths phases (GPs), generated by the heterogeneities on modular networks, have recently been suggested to provide a mechanism, rid of fine parameter tuning, to explain the critical behavior of complex systems. One conjectured requirement for systems with modular structures was that the network of modules must be hierarchically organized and possess finite dimension. We investigate the dynamical behavior of an activity spreading model, evolving on heterogeneous random networks with highly modular structure and organized non-hierarchically. We observe that loosely coupled modules act as effective rare-regions, slowing down the extinction of activation. As a consequence, we find extended control parameter regions with continuously changing dynamical exponents for single network realizations, preserved after finite size analyses, as in a real GP. The avalanche size distributions of spreading events exhibit robust power-law tails. Our findings relax the requirement of hierarchical organization of the modular structure, which can help to rationalize the criticality of modular systems in the framework of GPs.Item Local roughness exponent in the nonlinear molecular-beam-epitaxy universality class in one dimension(Physical Review, 2019-02) Ferreira, Silvio C.; Luis, Edwin E. Mozo; Assis, Thiago A. de; Andrade, Roberto F. S.We report local roughness exponents, αloc, for three interface growth models in one dimension which are believed to belong to the nonlinear molecular-beam-epitaxy (nMBE) universality class represented by the Villain-Lais-Das Sarma (VLDS) stochastic equation. We applied an optimum detrended fluctuation analysis (ODFA) [Luis et al., Phys. Rev. E 95, 042801 (2017)] and compared the outcomes with standard detrending methods. We observe in all investigated models that ODFA outperforms the standard methods providing exponents in the narrow interval αloc∈[0.96,0.98] quantitatively consistent with two-loop renormalization group predictions for the VLDS equation. In particular, these exponent values are calculated for the Clarke-Vvdensky and Das Sarma-Tamborenea models characterized by very strong corrections to the scaling, for which large deviations of these values had been reported. Our results strongly support the absence of anomalous scaling in the nMBE universality class and the existence of corrections in the form αloc=1−ε of the one-loop renormalization group analysis of the VLDS equation.Item Multiple transitions of the susceptible-infected-susceptible epidemic model on complex networks(Physical Review E, 2015-01-22) Mata, Angélica S.; Ferreira, Silvio C.The epidemic threshold of the susceptible-infected-susceptible (SIS) dynamics on random networks having a power law degree distribution with exponent γ > 3 has been investigated using different mean-field approaches, which predict different outcomes. We performed extensive simulations in the quasistationary state for a comparison with these mean-field theories. We observed concomitant multiple transitions in individual networks presenting large gaps in the degree distribution and the obtained multiple epidemic thresholds are well described by different mean-field theories. We observed that the transitions involving thresholds which vanish at the thermodynamic limit involve localized states, in which a vanishing fraction of the network effectively contributes to epidemic activity, whereas an endemic state, with a finite density of infected vertices, occurs at a finite threshold. The multiple transitions are related to the activations of distinct subdomains of the network, which are not directly connected.Item Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer(Physical Biology, 2013-03-15) Paiva, Leticia R .; Silva, Hallan S.; Ferreira, Silvio C.; Martins, Marcelo L.Oncolytic virotherapy—the use of viruses that specifically kill tumor cells—is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection. In this paper, we propose a multiscale mathematical model to study how the immune response interferes with the viral oncolytic activity. The model assumes that cytotoxic T cells can induce apoptosis in infected cancer cells and that free viruses can be inactivated by neutralizing antibodies or cleared at a constant rate by the innate immune response. Our simulations suggest that reprogramming the immune microenvironment in tumors could substantially enhance the oncolytic virotherapy in immune-competent hosts. Viable routes to such reprogramming are either in situ virus-mediated impairing of CD8 + T cells motility or blockade of B and T lymphocytes recruitment. Our theoretical results can shed light on the design of viral vectors or new protocols with neat potential impacts on the clinical practice.Item Optimal detrended fluctuation analysis as a tool for the determination of the roughness exponent of the mounded surfaces(Physical Review E, 2018-02-05) Luis, Edwin E. Mozo; Assis, Thiago A. de; Ferreira, Silvio C.We present an optimal detrended fluctuation analysis (DFA) and applied it to evaluate the local roughness exponent in non-equilibrium surface growth models with mounded morphology. Our method consists in analyzing the height fluctuations computing the shortest distance of each point of the profile to a detrending curved that fits the surface within the investigated interval. We compare the optimal DFA (ODFA) with both the standard DFA and nondetrended analysis. We validate the ODFA method considering a one-dimensional model in the Kardar-Parisi-Zhang universality class starting from a mounded initial condition. We applied the methods to the Clarke-Vvdensky (CV) model in 2 + 1 dimensions with thermally activated surface diffusion and absence of step barriers. It is expected that this model belongs to the nonlinear Molecular Beam Epitaxy (nMBE) universality class. However, an explicit observation of the roughness exponent in agreement with the nMBE class was still missing. The effective roughness exponent obtained with ODFA agrees with the value expected for nMBE class whereas using the other methods it does not. We also characterized the transient anomalous scaling of the CV model and obtained that the corresponding exponent is in agreement with the value reported for other nMBE models with weaker corrections to the scaling.Item Optimized Gillespie algorithms for the simulation of Markovian epidemic processes on large and heterogeneous networks(Computer Physics Communications, 2017-10) Cota, Wesley; Ferreira, Silvio C.Numerical simulation of continuous-time Markovian processes is an essential and widely applied tool in the investigation of epidemic spreading on complex networks. Due to the high heterogeneity of the connectivity structure through which epidemic is transmitted, efficient and accurate implementations of generic epidemic processes are not trivial and deviations from statistically exact prescriptions can lead to uncontrolled biases. Based on the Gillespie algorithm (GA), in which only steps that change the state are considered, we develop numerical recipes and describe their computer implementations for statistically exact and computationally efficient simulations of generic Markovian epidemic processes aiming at highly heterogeneous and large networks. The central point of the recipes investigated here is to include phantom processes, that do not change the states but do count for time increments. We compare the efficiencies for the susceptible–infected–susceptible, contact process and susceptible–infected–recovered models, that are particular cases of a generic model considered here. We numerically confirm that the simulation outcomes of the optimized algorithms are statistically indistinguishable from the original GA and can be several orders of magnitude more efficient.Item Origins of scaling corrections in ballistic growth models(Physical Review E, 2014-11-20) Alves, Sidiney G.; Oliveira, Tiago J.; Ferreira, Silvio C.We study the ballistic deposition and the grain deposition models on two-dimensional substrates. Using the Kardar-Parisi-Zhang (KPZ) ansatz for height fluctuations, we show that the main contribution to the intrinsic width, which causes strong corrections to the scaling, comes from the fluctuations in the height increments along deposition events. Accounting for this correction in the scaling analysis, we obtain scaling exponents in excellent agreement with the KPZ class. We also propose a method to suppress these corrections, which consists in dividing the surface in bins of size ε and using only the maximal height inside each bin to do the statistics. Again, scaling exponents in remarkable agreement with the KPZ class are found. The binning method allows the accurate determination of the height distributions of the ballistic models in both growth and steady-state regimes, providing the universal underlying fluctuations foreseen for KPZ class in 2 + 1 dimensions. Our results provide complete and conclusive evidences that the ballistic model belongs to the KPZ universality class in 2 + 1 dimensions. Potential applications of the methods developed here, in both numerics and experiments, are discussed.Item Phase transitions with infinitely many absorbing states in complex networks(Physical Review E, 2013-02-27) Sander, Renan S.; Ferreira, Silvio C.; Pastor-Satorras, RomualdoWe investigate the properties of the threshold contact process (TCP), a process showing an absorbing-state phase transition with infinitely many absorbing states, on random complex networks. The finite-size scaling exponents characterizing the transition are obtained in a heterogeneous mean-field (HMF) approximation and compared with extensive simulations, particularly in the case of heterogeneous scale-free networks. We observe that the TCP exhibits the same critical properties as the contact process, which undergoes an absorbing-state phase transition to a single absorbing state. The accordance among the critical exponents of different models and networks leads to conjecture that the critical behavior of the contact process in a HMF theory is a universal feature of absorbing-state phase transitions in complex networks, depending only on the locality of the interactions and independent of the number of absorbing states. The conditions for the applicability of the conjecture are discussed considering a parallel with the susceptible-infected-susceptible epidemic spreading model, which in fact belongs to a different universality class in complex networks.Item Quasistationary analysis of the contact process on annealed scale-free networks(Statistical Mechanics, 2011-06-20) Ferreira, Silvio C.; Ferreira, Ronan S.; Pastor-Satorras, RomualdoWe present an analysis of the quasistationary (QS) state of the contact process (CP) on annealed scale-free networks using a mapping of the CP dynamics in a one-step process and analyzing numerically and analytically the corresponding master equation. The relevant QS quantities determined via the master equation exhibit an excellent agreement with direct QS stochastic simulations of the CP. The high accuracy of the resulting data allows a probe of the strong corrections to scaling present in both the critical and supercritical regions, corrections that mask the correct finite-size scaling obtained analytically by applying an exact heterogeneous mean-field approach. Our results represent a promising starting point for a deeper understanding of the contact process and absorbing phase transitions on real (quenched) complex networks.Item Quasistationary simulations of the contact process on quenched networks(Physical Review E, 2011-12-05) Ferreira, Silvio C.; Ferreira, Ronan S.; Castellano, Claudio; Pastor-Satorras, RomualdoWe present high-accuracy quasistationary (QS) simulations of the contact process in quenched networks, built using the configuration model with both structural and natural cutoffs. The critical behavior is analyzed in the framework of the anomalous finite-size scaling which was recently shown to hold for the contact process on annealed networks. It turns out that the quenched topology does not qualitatively change the critical behavior, leading only (as expected) to a shift of the transition point. The anomalous finite-size scaling holds with exactly the same exponents of the annealed case, so we can conclude that heterogeneous mean-field theory works for the contact process on quenched networks, at odds with previous claims. Interestingly, topological correlations induced by the presence of the natural cutoff do not alter the pictureItem Robustness and fragility of the susceptible- infected- susceptible epidemic models on complex networks(Physical Review E, 2018) Cota, Wesley; Mata, Angélica S.; Ferreira, Silvio C.We analyze two alterations of the standard susceptible-infected-susceptible (SIS) dynamics that preserve the central properties of spontaneous healing and infection capacity of a vertex increasing unlimitedly with its degree. All models have the same epidemic thresholds in mean-field theories but depending on the network properties, simulations yield a dual scenario, in which the epidemic thresholds of the modified SIS models can be either dramatically altered or remain unchanged in comparison with the standard dynamics. For uncorrelated synthetic networks having a power-law degree distribution with exponent γ<5/2, the SIS dynamics are robust exhibiting essentially the same outcomes for all investigated models. A threshold in better agreement with the heterogeneous rather than quenched mean-field theory is observed in the modified dynamics for exponent γ>5/2. Differences are more remarkable for γ>3, where a finite threshold is found in the modified models in contrast with the vanishing threshold of the original one. This duality is elucidated in terms of epidemic lifespan on star graphs. We verify that the activation of the modified SIS models is triggered in the innermost component of the network given by a k-core decomposition for γ<3 while it happens only for γ<5/2 in the standard model. For γ>3, the activation in the modified dynamics is collective involving essentially the whole network while it is triggered by hubs in the standard SIS. The duality also appears in the finite-size scaling of the critical quantities where mean-field behaviors are observed for the modified but not for the original dynamics. Our results feed the discussions about the most proper conceptions of epidemic models to describe real systems and the choices of the most suitable theoretical approaches to deal with these models.