Navegando por Autor "Oliveira, T.T."
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Item Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations(Pharmacological Research, 1999-05-26) Santos, K.F.R.; Oliveira, T.T.; Nagem, T.J.; Pinto, A.S.; Oliveira, M.G.A.Atherosclerosis can be defined as being a disease of coronary circulation. The present work evaluates the action of the naringenin, rutin, nicotinic acid, isolated and in association, on the metabolism of lipids. Cholesterol, cholesterol HDL, and triacylglycerols have been dosed after retreat of blood, following the administration of the compounds dissolved in propylene glycol by intraperitoneal route in doses of 5 mg kg^−1body wt. Results evidence that naringenin and nicotinic acid, isolated as well as their association with naringenin and nicotinic acid–rutin, present the largest percentual reduction of cholesterol. On the other hand, the best results for cholesterol-HDL have been obtained with naringenin, while rutin has shown the best triacylglycerols levels.Item In vitro inhibition of canine distemper virus by flavonoids and phenolic acids: Implications of structural differences for antiviral design(Research in Veterinary Science, 2013-04-08) Carvalho, O.V.; Botelho, C.V.; Ferreira, C.G.T.; Ferreira, H.C.C.; Santos, M.R.; Diaz, M.A.N.; Oliveira, T.T.; Martins, J.A.P. Soares; Almeida, M.R.; Silva Júnior, A.Infection caused by canine distemper virus (CDV) is a highly contagious disease with high incidence and lethality in the canine population. Antiviral activity of flavonoids quercetin, morin, rutin and hesperidin, and phenolic cinnamic, trans-cinnamic and ferulic acids were evaluated in vitro against the CDV using the time of addition assay to determine which step of the viral replicative cycle was affected. All flavonoids displayed great viral inhibition when they were added at the times 0 (adsorption) and 1 h (penetration) of the viral replicative cycle. Both quercetin and hesperidin presented antiviral activity at the time 2 h (intracellular). In the other hand, cinnamic acid showed antiviral activity at the times 0 and 2 h while trans-cinnamic acid showed antiviral effect at the times À1 h (pre-treatment) and 0 h. Ferulic acid inhibited CDV replicative cycle at the times 0 and 1 h. Our study revealed promising candidates to be consid- ered in the treatment of CDV. Structural differences among compounds and correlation to their antiviral activity were also explored. Our analysis suggest that these compounds could be useful in order to design new antiviral drugs against CDV as well as other viruses of great meaning in veterinary medicine.