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Campo DC | Valor | Idioma |
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dc.contributor.author | Rodrigues, Joel Alves | - |
dc.contributor.author | Prímola-Gomes, Thales Nicolau | - |
dc.contributor.author | Leal, Tiago Ferreira | - |
dc.contributor.author | Pedrosa, Danillo Laviola | - |
dc.contributor.author | Rezende, Leonardo Mateus Teixeira | - |
dc.contributor.author | Natali, Antonio Jose | - |
dc.contributor.author | Nóbrega, Clara | - |
dc.contributor.author | Oliveira, Edilamar Menezes de | - |
dc.date.accessioned | 2022-08-08T18:25:18Z | - |
dc.date.available | 2022-08-08T18:25:18Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1678-4170 | - |
dc.identifier.uri | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001400172 | - |
dc.identifier.uri | https://locus.ufv.br//handle/123456789/29581 | - |
dc.description | Link errado. Favor verificar. | pt-BR |
dc.description.abstract | Regulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups -sedentary hypertensive (SH); trained hypertensive (TH); sedentary normotensive (SN); and trained normotensive (TN). Animals of the TH and TN groups were subjected to treadmill running program, 5 days/week, 1 hour/day at 60-70% of maximum running velocity for 8 weeks. We adopted a p ≤ 0.05 as significance level for all comparisons. Exercise training reduced systolic arterial pressure in hypertensive rats. In normotensive rats, exercise training reduced the time to 50% cell relaxation and the time to peak contraction and increased the time to 50% decay of the intracellular Ca2+ transients. In SHR, exercise increased the amplitude and reduced the time to 50% decay of Ca2+transients. Exercise training increased the expression of miR-214 in hypertensive rats only. The aerobic training applied in this study increased the availability of intracellular Ca2+ and accelerated the sequestration of these ions in left ventricular myocytes of hypertensive rats, despite increased expression of miR-214 and maintenance of cell contractility. | pt-BR |
dc.format | pt-BR | |
dc.language.iso | eng | pt-BR |
dc.publisher | Arquivos Brasileiros de Cardiologia | pt-BR |
dc.relation.ispartofseries | v. 111, n. 02, p. 172-179, ago. 2018 | pt-BR |
dc.rights | Open Access | pt-BR |
dc.subject | Hypertension | pt-BR |
dc.subject | Exercise | pt-BR |
dc.subject | Rats | pt-BR |
dc.subject | Calcium signaling | pt-BR |
dc.subject | Intracellular calcium | pt-BR |
dc.subject | Sensing Proteins | pt-BR |
dc.title | Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats | pt-BR |
dc.type | Artigo | pt-BR |
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