Dengue virus–specific antibodies enhance brazilian Zika vrus infection

Castanha, Priscila M. S.; Nascimento, Eduardo J. M.; Braga, Cynthia; Cordeiro, Marli T.; Carvalho, Otávio V. de; Mendonça, Leila R. de; Azevedo, Elisa A. N.; França, Rafael F. O.; Dhalia, Rafael; Marques, Ernesto T. A.

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Campo DC	Valor	Idioma
dc.contributor.author	Castanha, Priscila M. S.
dc.contributor.author	Nascimento, Eduardo J. M.
dc.contributor.author	Braga, Cynthia
dc.contributor.author	Cordeiro, Marli T.
dc.contributor.author	Carvalho, Otávio V. de
dc.contributor.author	Mendonça, Leila R. de
dc.contributor.author	Azevedo, Elisa A. N.
dc.contributor.author	França, Rafael F. O.
dc.contributor.author	Dhalia, Rafael
dc.contributor.author	Marques, Ernesto T. A.
dc.date.accessioned	2017-12-12T17:07:05Z
dc.date.available	2017-12-12T17:07:05Z
dc.date.issued	2016-12-30
dc.identifier.issn	1537-6613
dc.identifier.uri	https://doi.org/10.1093/infdis/jiw638
dc.identifier.uri	http://www.locus.ufv.br/handle/123456789/14857
dc.description.abstract	Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.	en
dc.format	pdf	pt-BR
dc.language.iso	eng	pt-BR
dc.publisher	The Journal of Infectious Diseases	pt-BR
dc.relation.ispartofseries	215(5), p. 781-785, Mar. 2017	pt-BR
dc.rights	Open Access	pt-BR
dc.subject	Zika virus	pt-BR
dc.subject	Antibody dependent enhancement	pt-BR
dc.subject	Dengue antibodies	pt-BR
dc.title	Dengue virus–specific antibodies enhance brazilian Zika vrus infection	en
dc.type	Artigo	pt-BR
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