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URI permanente para esta coleçãohttps://locus.ufv.br/handle/123456789/11800

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2011 - 20132

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Data inicial: 2010Data final: 2013Autor: search.filters.author.Rubinger, Mayura M. M.

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    Synthesis and antifungal activity of halogenated aromatic bis-γ-lactones analogous to avenaciolide
    (Química Nova, 2011-11-08) Castelo-Branco, Pedro A.; Rubinger, Mayura M. M.; Alves, Leandro de C.; Liberto, Natalia A.; Nepel, Thayane C. M.; Catrinck, Mariana; Guilardi, Silvana; Silvério, Hudson A.; Zambolim, Laércio; Piló-Veloso, Dorila; F. Neto, Wilson P.
    Here we describe the total syntheses and characterization by elemental analyses, infrared and NMR spectroscopy of three new compounds analogous to avenaciolide, a bis-γ-lactone isolated from Aspergillus avenaceus that possesses antifungal activity, where the octyl group of the natural product was replaced by aromatic groups containing chlorine and fluorine atoms. The effects of the avenaciolide, the novel compounds and their synthetic precursors on mycelia development and conidia germination of Colletotrichum gloeosporioides and Fusarium solani were evaluated in vitro. The title compounds were almost as active as avenaciolide. The absolute structures of the chlorinated analogs were determined by X-ray diffraction analysis.
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    Syntheses, characterization and antifungal activity of tris(1,10-phenanthroline)iron(ii) bis(n-r-sulfonyldithiocarbimate)zincate(ii)
    (Química Nova, 2013-05-25) Bottega, Fernanda C.; Oliveira, Marcelo R. L.; Garcia, Camila V.; Menezes, Daniele C.; Rubinger, Mayura M. M.; Zambolim, Laercio
    Four new compounds with the general formula [Fe(phen)3][Zn(RSO2N=CS2)2], where phen = 1,10-phenanthroline, R = 4-FC6H4 (1), 4-ClC6H4 (2), 4-BrC6H4 (3) and 4-IC6H4 (4), respectively, were obtained by the reaction of the appropriate potassium N-R-sulfonyldithiocarbimate (RSO2N=CS2K2) and tris(1,10-phenanthroline)iron(II) sulfate, with zinc(II) acetate dihydrate in dimethylformamide. The elemental analyses and the IR data were consistent with the formation of the expected complexes salts. The 1H and 13C NMR spectra showed the signals for the cationic iron(II) complex and dithiocarbimate moieties. The molar conductance data were consistent with the 1:1 cation:anion complexes in 1-4. The antifungal activities of the compounds were tested in vitro against Candida albicans, Candida tropicalis and Colletotrichum gloeosporioides.