Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/23846
Tipo: Artigo
Título: Aggregation behavior of self-assembled nanoparticles made from carboxymethyl-hexanoyl chitosan and sodium dodecyl sulphate surfactant in water
Autor(es): Agudelo, Alvaro J. P.
Silva, Luis H. M. da
Rengifo, Andrés F. C.
Santos, Sandra C.
Lima, Vania R. de
Parize, Alexandre L.
Minatti, Edson
Abstract: Biopolymers can be used to produce nano-objects in solution and they are generally of low cost and biocompatible. However, they commonly have low kinetic stability and form aggregates with a broad particle size distribution, characteristics that hinder their use in drug delivery systems. Herein, we report the thermodynamics and mechanisms underlying the formation of nanostructures through the self-assembly of carboxymethyl-hexanoyl chitosan (ONCHC) and the effect of the presence of the surfactant sodium dodecyl sulfate (SDS). The pre- and post-aggregation regimes were monitored using several techniques and indicated that self-assembly is thermodynamically favorable. The presence of SDS decreased the hydrodynamic radius and surface charge of the SDS-ONCHC nanoaggregates and increased the kinetic stability in aqueous solution over a period of 150 days. The SDS-ONCHC interaction is driven mainly by a hydrophobic effect and the addition of SDS increases the number and strength of the hydrophobic domains, where the integral enthalpy change for the aggregate formation is −2.11 kJ mol−1.
Palavras-chave: Carboxymethyl-hexanoyl chitosan
Polymer surfactant complex
Isothermal titration calorimetry (ITC)
Conductivity
Dynamic light-scattering (DLS)
Surface tension
Editor: Journal of Molecular Liquids
Tipo de Acesso: Elsevier B. V.
URI: https://doi.org/10.1016/j.molliq.2018.12.125
http://www.locus.ufv.br/handle/123456789/23846
Data do documento: 15-Mar-2019
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