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https://locus.ufv.br//handle/123456789/23846
Tipo: | Artigo |
Título: | Aggregation behavior of self-assembled nanoparticles made from carboxymethyl-hexanoyl chitosan and sodium dodecyl sulphate surfactant in water |
Autor(es): | Agudelo, Alvaro J. P. Silva, Luis H. M. da Rengifo, Andrés F. C. Santos, Sandra C. Lima, Vania R. de Parize, Alexandre L. Minatti, Edson |
Abstract: | Biopolymers can be used to produce nano-objects in solution and they are generally of low cost and biocompatible. However, they commonly have low kinetic stability and form aggregates with a broad particle size distribution, characteristics that hinder their use in drug delivery systems. Herein, we report the thermodynamics and mechanisms underlying the formation of nanostructures through the self-assembly of carboxymethyl-hexanoyl chitosan (ONCHC) and the effect of the presence of the surfactant sodium dodecyl sulfate (SDS). The pre- and post-aggregation regimes were monitored using several techniques and indicated that self-assembly is thermodynamically favorable. The presence of SDS decreased the hydrodynamic radius and surface charge of the SDS-ONCHC nanoaggregates and increased the kinetic stability in aqueous solution over a period of 150 days. The SDS-ONCHC interaction is driven mainly by a hydrophobic effect and the addition of SDS increases the number and strength of the hydrophobic domains, where the integral enthalpy change for the aggregate formation is −2.11 kJ mol−1. |
Palavras-chave: | Carboxymethyl-hexanoyl chitosan Polymer surfactant complex Isothermal titration calorimetry (ITC) Conductivity Dynamic light-scattering (DLS) Surface tension |
Editor: | Journal of Molecular Liquids |
Tipo de Acesso: | Elsevier B. V. |
URI: | https://doi.org/10.1016/j.molliq.2018.12.125 http://www.locus.ufv.br/handle/123456789/23846 |
Data do documento: | 15-Mar-2019 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf Until 2100-12-31 | Texto completo | 1,2 MB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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