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https://locus.ufv.br//handle/123456789/22289
Tipo: | Artigo |
Título: | Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet |
Autor(es): | Sousa, Andressa Rodrigues de Moreira, Maria Eliza de Castro Toledo, Renata Celi Lopes Benjamin, Laércio dos Anjos Queiroz, Valéria Aparecida Vieira Veloso, Marcia Paranho Reis, Kassius de Souza Martino, Hércia Stampini Duarte |
Abstract: | The study investigated the effect of extruded sorghum flour (ESF) in a high fat diet (HFD) on biometric measurements and hepatic lipogenesis. Male Wistar rats were fed a normal diet (AIN-93M), HFD, HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50), or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100) for eight weeks. ESF reduced the body mass index and liver weight of obese rats. Additionally, ESF reduced hepatic lipogenesis by increasing adiponectin 2 receptor gene expression and gene and protein expressions of peroxisome proliferator-activated receptor α (PPARα), while reducing the gene expression of sterol regulatory element-binding transcription factor 1. Molecular docking analysis revealed the affinity of ESF compounds (luteolinidin, apigeninidin, 5-methoxy-luteolinidin, and 7-methoxy-apigeninidin) with the PPAR-α receptor. Histological analysis confirmed the decreased grade of hepatic steatosis in obese rats. These data indicate the potential of ESF to reduce metabolic risk of hepatic steatosis associated with lipogenesis and obesity. |
Palavras-chave: | Sorghum Adipogenese Anthocyanin Bioactive compounds β-Oxidation Tannins |
Editor: | Food Research International |
Tipo de Acesso: | Elsevier Ltd. |
URI: | https://doi.org/10.1016/j.foodres.2018.06.004 http://www.locus.ufv.br/handle/123456789/22289 |
Data do documento: | 4-Jun-2018 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf Until 2100-12-31 | texto completo | 2,17 MB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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