Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/22289
Tipo: Artigo
Título: Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet
Autor(es): Sousa, Andressa Rodrigues de
Moreira, Maria Eliza de Castro
Toledo, Renata Celi Lopes
Benjamin, Laércio dos Anjos
Queiroz, Valéria Aparecida Vieira
Veloso, Marcia Paranho
Reis, Kassius de Souza
Martino, Hércia Stampini Duarte
Abstract: The study investigated the effect of extruded sorghum flour (ESF) in a high fat diet (HFD) on biometric measurements and hepatic lipogenesis. Male Wistar rats were fed a normal diet (AIN-93M), HFD, HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50), or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100) for eight weeks. ESF reduced the body mass index and liver weight of obese rats. Additionally, ESF reduced hepatic lipogenesis by increasing adiponectin 2 receptor gene expression and gene and protein expressions of peroxisome proliferator-activated receptor α (PPARα), while reducing the gene expression of sterol regulatory element-binding transcription factor 1. Molecular docking analysis revealed the affinity of ESF compounds (luteolinidin, apigeninidin, 5-methoxy-luteolinidin, and 7-methoxy-apigeninidin) with the PPAR-α receptor. Histological analysis confirmed the decreased grade of hepatic steatosis in obese rats. These data indicate the potential of ESF to reduce metabolic risk of hepatic steatosis associated with lipogenesis and obesity.
Palavras-chave: Sorghum
Adipogenese
Anthocyanin
Bioactive compounds
β-Oxidation
Tannins
Editor: Food Research International
Tipo de Acesso: Elsevier Ltd.
URI: https://doi.org/10.1016/j.foodres.2018.06.004
http://www.locus.ufv.br/handle/123456789/22289
Data do documento: 4-Jun-2018
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