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https://locus.ufv.br//handle/123456789/17330
Tipo: | Artigo |
Título: | In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae) |
Autor(es): | Sartorelli, Patricia Santana, Jefferson S. Guadagnin, Rafael C. Lago, João Henrique G. Pinto, Érika G. Tempone, André G. Stefani, Hélio A. Soares, Marisi G. Silva, Adalberto M. da |
Abstract: | Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity. |
Palavras-chave: | Schinus terebinthifolius Raddi Anacardiaceae Trypanocidal activity |
Editor: | Química Nova |
Tipo de Acesso: | Open Access |
URI: | http://dx.doi.org/10.1590/S0100-40422012000400017 http://www.locus.ufv.br/handle/123456789/17330 |
Data do documento: | 23-Nov-2012 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
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artigo.pdf | Texto completo | 307,41 kB | Adobe PDF | Visualizar/Abrir |
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