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https://locus.ufv.br//handle/123456789/17021
Tipo: | Artigo |
Título: | Strychnos pseudoquina and its purified compounds present an effective in vitro antileishmanial activity |
Autor(es): | Lage, Paula Sousa Andrade, Pedro Henrique Rocha de Lopes, Amanda de Santana Fumagalli, Miguel Angel Chávez Valadares, Diogo Garcia Duarte, Mariana Costa Lage, Daniela Pagliara Costa, Lourena Emanuele Martins, Vivian Tamietti Ribeiro, Tatiana Gomes Souza Filho, José Dias de Tavares, Carlos Alberto Pereira Pádua, Rodrigo Maia de Leite, João Paulo Viana Coelho, Eduardo Antonio Ferraz |
Abstract: | The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity of Strychnos pseudoquina St. Hil. was investigated and pure compounds that presented this biological effect were isolated. An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazonensis. A bioactivity-guided fractionation was performed, and two flavonoids were identified, quercetin 3-O-methyl ether and strychnobiflavone, which presented an effective antileishmanial activity against L. amazonensis, and studies were extended to establish their minimum inhibitory concentrations (IC50), their leishmanicidal effects on the intra-macrophage Leishmania stage, as well as their cytotoxic effects on murine macrophages (CC50), and in O+ human red blood cells. The data presented in this study showed the potential of an ethyl acetate extract of S. pseudoquina, as well as two flavonoids purified from it, which can be used as a therapeutic alternative on its own, or in association with other drugs, to treat disease evoked by L. amazonensis. |
Palavras-chave: | Strychnos pseudoquina In Vitro |
Editor: | Evidence-Based Complementary and Alternative Medicine |
Tipo de Acesso: | Open Access |
URI: | http://dx.doi.org/10.1155/2013/304354 http://www.locus.ufv.br/handle/123456789/17021 |
Data do documento: | 28-Ago-2013 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
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artigo.pdf | texto completo | 1,41 MB | Adobe PDF | Visualizar/Abrir |
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