Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/17021
Tipo: Artigo
Título: Strychnos pseudoquina and its purified compounds present an effective in vitro antileishmanial activity
Autor(es): Lage, Paula Sousa
Andrade, Pedro Henrique Rocha de
Lopes, Amanda de Santana
Fumagalli, Miguel Angel Chávez
Valadares, Diogo Garcia
Duarte, Mariana Costa
Lage, Daniela Pagliara
Costa, Lourena Emanuele
Martins, Vivian Tamietti
Ribeiro, Tatiana Gomes
Souza Filho, José Dias de
Tavares, Carlos Alberto Pereira
Pádua, Rodrigo Maia de
Leite, João Paulo Viana
Coelho, Eduardo Antonio Ferraz
Abstract: The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity of Strychnos pseudoquina St. Hil. was investigated and pure compounds that presented this biological effect were isolated. An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazonensis. A bioactivity-guided fractionation was performed, and two flavonoids were identified, quercetin 3-O-methyl ether and strychnobiflavone, which presented an effective antileishmanial activity against L. amazonensis, and studies were extended to establish their minimum inhibitory concentrations (IC50), their leishmanicidal effects on the intra-macrophage Leishmania stage, as well as their cytotoxic effects on murine macrophages (CC50), and in O+ human red blood cells. The data presented in this study showed the potential of an ethyl acetate extract of S. pseudoquina, as well as two flavonoids purified from it, which can be used as a therapeutic alternative on its own, or in association with other drugs, to treat disease evoked by L. amazonensis.
Palavras-chave: Strychnos pseudoquina
In Vitro
Editor: Evidence-Based Complementary and Alternative Medicine
Tipo de Acesso: Open Access
URI: http://dx.doi.org/10.1155/2013/304354
http://www.locus.ufv.br/handle/123456789/17021
Data do documento: 28-Ago-2013
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