Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/14862
Tipo: Artigo
Título: Synthesis and antifungal activity of aromatic bis-g-lactones analogous to avenaciolide
Autor(es): Castelo-Branco, Pedro A.
Rubinger, Mayura M. M.
Alves, Leandro de C.
Barros, Pauline M. de
Pereira, Sinval G.
Melo, Vanessa J. de
Pilo-Veloso, Dorila
Zambolim, Laércio
Abstract: Avenaciolide is a bis-γ-lactone isolated from Aspergillus avenaceus and possesses antifungal activity. Here, we describe the total syntheses and characterization by elemental analyses, and IR and NMR spectroscopy of three new bis-γ-lactones analogous to avenaciolide, where the octyl group of the natural product was replaced by aromatic groups. The effects of the avenaciolide, the novel compounds, and their synthetic precursors on the mycelia development and conidia germination of Colletotrichum gloeosporioides were evaluated in vitro. The new compounds were as active as avenaciolide in the tested conditions, while the synthetic precursors were inactive. The preparation and characterization of 15 new synthetic intermediates are also described.
Palavras-chave: Synthesis and antifungal activity
Bis-gamma-lactones
Editor: Chemistry & Biodiversity
Tipo de Acesso: Open Access
URI: http://dx.doi.org/10.1002/cbdv.200790223
http://www.locus.ufv.br/handle/123456789/14862
Data do documento: 13-Fev-2007
Aparece nas coleções:Artigos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Castelo-Branco_et_al-2007-Chemistry_&_Biodiversity.pdftexto completo205,88 kBAdobe PDFThumbnail
Visualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.