Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/14554
Tipo: Artigo
Título: Proparacaine complexation with β-cyclodextrin and p-sulfonic acid calix[6]arene, as evaluated by varied 1 H-NMR approaches
Autor(es): Arantes, Lucas Micquéias
Scarelli, Camilla
Marsaioli, Anita Jocelyne
Paula, Eneida de
Fernandes, Sergio Antonio
Abstract: This study focused on the use of NMR techniques as a tool for the investigation of complex formation between proparacaine and cyclodextrins (CDs) or p-sulfonic acid calix[6]arene. The pH dependence of the complexation of proparacaine with β-CD and p-sulfonic acid calix[6]arene was studied and binding constants were determined by 1H NMR spectroscopy [diffusion-ordered spectroscopy (DOSY)] for the charged and uncharged forms of the local anesthetic in β-CD and p-sulfonic acid calix[6]arene. The stoichiometries of the complexes was determined and rotating frame Overhauser enhancement spectroscopy (ROESY) 1D experiments revealed details of the molecular insertion of proparacaine into the β-CD and p-sulfonic acid calix[6]arene cavities. The results unambiguously demonstrate that pH is an important factor for the development of supramolecular architectures based on β-CD and p-sulfonic acid calix[6]arene as the host molecules. Such host–guest complexes were investigated in view of their potential use as new therapeutic formulations, designed to increase the bioavailability and/or to decrease the systemic toxicity of proparacaine in anesthesia procedures.
Palavras-chave: Proparacaine
Cyclodextrin
Calixarenes
NMR
Editor: Magnetic Resonance in Chemistry
Tipo de Acesso: Open Access
URI: http://dx.doi.org/10.1002/mrc.2460
http://www.locus.ufv.br/handle/123456789/14554
Data do documento: 25-Jun-2009
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