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https://locus.ufv.br//handle/123456789/12889
Tipo: | Artigo |
Título: | Zero-inflated Poisson regression models for QTL mapping applied to tick-resistance in a Gyr x Holstein F2 population |
Autor(es): | Silva, Fabyano Fonseca Tunin, Karen P. Rosa, Guilherme J.M. Silva, Marcos V.B. da Azevedo, Ana Luisa Souza Verneque, Rui da Silva Machado, Marco Antonio Packer, Irineu Umberto |
Abstract: | Nowadays, an important and interesting alternative in the control of tick-infestation in cattle is to select resistant animals, and identify the respective quantitative trait loci (QTLs) and DNA markers, for posterior use in breeding programs. The number of ticks/animal is characterized as a discrete-counting trait, which could potentially follow Poisson distribution. However, in the case of an excess of zeros, due to the occurrence of several noninfected animals, zero-inflated Poisson and generalized zero-inflated distribution (GZIP) may provide a better description of the data. Thus, the objective here was to compare through simulation, Poisson and ZIP models (simple and generalized) with classical approaches, for QTL mapping with counting phenotypes under different scenarios, and to apply these approaches to a QTL study of tick resistance in an F2 cattle (Gyr x Holstein) population. It was concluded that, when working with zero-inflated data, it is recommendable to use the generalized and simple ZIP model for analysis. On the other hand, when working with data with zeros, but not zero-inflated, the Poisson model or a data-transformation-approach, such as square-root or Box-Cox transformation, are applicable. |
Palavras-chave: | Dairy cattle Tick infestation QTL regression Generalized linear model |
Editor: | Genetics and Molecular Biology |
Tipo de Acesso: | Open Access |
URI: | http://dx.doi.org/10.1590/S1415-47572011005000049 http://www.locus.ufv.br/handle/123456789/12889 |
Data do documento: | 28-Out-2011 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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2011-076.pdf | texto completo | 837,57 kB | Adobe PDF | Visualizar/Abrir |
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