Use este identificador para citar ou linkar para este item:
https://locus.ufv.br//handle/123456789/19572
Tipo: | Artigo |
Título: | Synthetic vaccine (SBm7462) against the cattle tick Rhipicephalus (Boophilus) microplus: Preservation of immunogenic determinants in different strains from South America |
Autor(es): | Peconick, A.P. Sossai, S. Girão, F.A. Rodrigues, M.Q.R.B. Silva, C.H. Souza e Guzman Q, F. Patarroyo V, A.M. Vargas, M.I. Patarroyo, J.H. |
Abstract: | The synthetic vaccine SBm7462 is based on three immunogenic epitopes (4822, 4823 and 4824) contained within protein Bm86 derived from the Australian Yeerongpilly strain of the tick Rhipicephalus (Boophilus) microplus. Twenty strains of the tick originating from Brazil, Argentina, Colombia and Uruguay were analysed in order to identify differences compared with sequences present in components of vaccine SBm7462. For each parasite population, three cDNA fragments containing the nucleotides coding for the epitopes 4822, 4824 and 4823 were sequenced, and the amino acid sequences were deduced and compared with those of the homologous bm86 gene. The results indicate that the epitope sequences of vaccine SBm7462 are conserved in the South American populations of the tick. The conservation of such sequences is very important for the immunological response of different populations of R. (B.) microplus. |
Palavras-chave: | Rhipicephalus (Boophilus) microplus Tick Protein Bm86 Protein Bm95 Conserved epitope sequences Synthetic vaccine Polymerase chain reaction (PCR) Base pair (bp) Amino acids (a.a.) |
Editor: | Experimental Parasitology |
Tipo de Acesso: | Elsevier Inc. |
URI: | https://doi.org/10.1016/j.exppara.2007.12.007 http://www.locus.ufv.br/handle/123456789/19572 |
Data do documento: | 23-Dez-2007 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
artigo.pdf Until 2100-12-31 | Texto completo | 368,46 kB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.