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https://locus.ufv.br//handle/123456789/21645
Tipo: | Artigo |
Título: | Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
Autor(es): | Santos, Marcelo H. dos Rocha, Cláudia Q. da Vilela, Fabiana C. Cecília, Flávia V. Santa Cavalcante, Gustavo P. Vilegas, Wagner Paiva, Alexandre Giusti |
Abstract: | Arrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use. |
Palavras-chave: | Arrabidaea brachypoda Inflammation Natural product Pain Triterpene |
Editor: | Revista Brasileira de Farmacognosia |
Tipo de Acesso: | Elsevier B.V. |
URI: | http://dx.doi.org/10.1016/j.bjp.2015.03.005 http://www.locus.ufv.br/handle/123456789/21645 |
Data do documento: | Mai-2015 |
Aparece nas coleções: | Artigos |
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artigo.pdf Until 2100-12-31 | Texto completo | 659,53 kB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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