Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/21645
Tipo: Artigo
Título: Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda
Autor(es): Santos, Marcelo H. dos
Rocha, Cláudia Q. da
Vilela, Fabiana C.
Cecília, Flávia V. Santa
Cavalcante, Gustavo P.
Vilegas, Wagner
Paiva, Alexandre Giusti
Abstract: Arrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use.
Palavras-chave: Arrabidaea brachypoda
Inflammation
Natural product
Pain
Triterpene
Editor: Revista Brasileira de Farmacognosia
Tipo de Acesso: Elsevier B.V.
URI: http://dx.doi.org/10.1016/j.bjp.2015.03.005
http://www.locus.ufv.br/handle/123456789/21645
Data do documento: Mai-2015
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