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https://locus.ufv.br//handle/123456789/21528
Tipo: | Artigo |
Título: | Cell aggregation in monolayer culture: Clues to a universal kinetics |
Autor(es): | Santos, A.A. Martins, M.L. Alves, S.G. Silva, P.C.A. da |
Abstract: | Aggregation of animal cells in culture comprises a series of motility, collision and adhesion processes of basic relevance for tissue engineering, bioseparations, oncology research and in vitro drug testing. In the present paper, we characterize the aggregation kinetics of normal and cancer cells in culture by determining their cluster size distribution functions. Our experiments reveal that the complementary cumulative distributions for eight cell lines from epithelial and mesenchymal origins are described by stretched exponential functions. Also, we find that as time evolves and the cell density increases, a dynamical phase transition occurs from an aggregation regime described by monotonically decreasing cluster size distributions to another one in which these distributions are nonmonotonic, exhibiting local maxima at large cluster sizes. Subtly, the universality of the stretched exponential distributions admits distinct cluster growth processes controlled by motility and adhesion traits of the cells. |
Palavras-chave: | Aggregation processes Cell culture Cluster size distributions Hybrid agent-based modeling |
Editor: | Physica A: Statistical Mechanics and its Applications |
Tipo de Acesso: | Elsevier B.V |
URI: | https://doi.org/10.1016/j.physa.2018.07.035 http://www.locus.ufv.br/handle/123456789/21528 |
Data do documento: | 18-Jul-2018 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf Until 2100-12-31 | Texto completo | 2,49 MB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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