Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/19492
Tipo: Artigo
Título: The phytoecdysteroid β-ecdysone is genotoxic in Rodent Bone Marrow Micronuclei and Allium cepa L. Assays
Autor(es): Neves, Camila Siqueira
Gomes, Shaiany Sabrina Lopes
Santos, Tatianne Rosa dos
Almeida, Mariana Macedo de
Souza, Yamara Oliveira de
Garcia, Raúl Marcel González
Otoni, Wagner Campos
Chedier, Luciana Moreira
Viccini, Lyderson Facio
Campos, José Marcello Salabert de
Abstract: Ethnaopharmacologial relevance In South America, the β-ecdysone ecdysteroid has been found in species of the genus Pfaffia Mart. Due to the similar morphology of its roots to the Panax ginseng C. A. Mey. (Korean ginseng), some species of this genus has been known as Brazilian ginseng and have been used as tonic and aphrodisiac, as well as for the treatment of diabetes and rheumatism. Here we report a cytogenotoxic evaluation of β-ecdysone (a natural ecdysteroid found in plants) in Rodent Bone Marrow Micronuclei and Allium cepa Assays. Three β-ecdysone (pure) concentrations (based in human therapeutic dosage) were used in the Micronucleus Assay. The animals were treated during two consecutive days. Micronucleated cells were counted in 2000 polychromatic erythrocytes per animal. For A. cepa L. Assay, one β-ecdysone concentration was analyzed. The onions bulbs were exposed for 24 h. The Micronucleus Assay showed genotoxic effects for all treatments, expressed by an increase of micronucleated cells. In A. cepa L. Assay, cell abnormalities associated to the malfunction/non-formation of mitotic spindle (aneugenic effect) and chromosomal bridges (clastogenic effect) were observed. The results indicate a cytogenotoxic activity of β-ecdysone. Therefore, the popular use of Pfaffia and others species containing β-ecdysone should be considered with caution.
Palavras-chave: Pfaffia glomerata
Brazilian ginseng
Cytogenotoxicity
Rodent bone marrow micronucleus Assay
Allium cepa Assay
β-ecdysone
Editor: Journal of Ethnopharmacology
Tipo de Acesso: Elsevier Ireland Ltd.
URI: https://doi.org/10.1016/j.jep.2015.11.038
http://www.locus.ufv.br/handle/123456789/19492
Data do documento: 25-Nov-2015
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