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https://locus.ufv.br//handle/123456789/19492
Tipo: | Artigo |
Título: | The phytoecdysteroid β-ecdysone is genotoxic in Rodent Bone Marrow Micronuclei and Allium cepa L. Assays |
Autor(es): | Neves, Camila Siqueira Gomes, Shaiany Sabrina Lopes Santos, Tatianne Rosa dos Almeida, Mariana Macedo de Souza, Yamara Oliveira de Garcia, Raúl Marcel González Otoni, Wagner Campos Chedier, Luciana Moreira Viccini, Lyderson Facio Campos, José Marcello Salabert de |
Abstract: | Ethnaopharmacologial relevance In South America, the β-ecdysone ecdysteroid has been found in species of the genus Pfaffia Mart. Due to the similar morphology of its roots to the Panax ginseng C. A. Mey. (Korean ginseng), some species of this genus has been known as Brazilian ginseng and have been used as tonic and aphrodisiac, as well as for the treatment of diabetes and rheumatism. Here we report a cytogenotoxic evaluation of β-ecdysone (a natural ecdysteroid found in plants) in Rodent Bone Marrow Micronuclei and Allium cepa Assays. Three β-ecdysone (pure) concentrations (based in human therapeutic dosage) were used in the Micronucleus Assay. The animals were treated during two consecutive days. Micronucleated cells were counted in 2000 polychromatic erythrocytes per animal. For A. cepa L. Assay, one β-ecdysone concentration was analyzed. The onions bulbs were exposed for 24 h. The Micronucleus Assay showed genotoxic effects for all treatments, expressed by an increase of micronucleated cells. In A. cepa L. Assay, cell abnormalities associated to the malfunction/non-formation of mitotic spindle (aneugenic effect) and chromosomal bridges (clastogenic effect) were observed. The results indicate a cytogenotoxic activity of β-ecdysone. Therefore, the popular use of Pfaffia and others species containing β-ecdysone should be considered with caution. |
Palavras-chave: | Pfaffia glomerata Brazilian ginseng Cytogenotoxicity Rodent bone marrow micronucleus Assay Allium cepa Assay β-ecdysone |
Editor: | Journal of Ethnopharmacology |
Tipo de Acesso: | Elsevier Ireland Ltd. |
URI: | https://doi.org/10.1016/j.jep.2015.11.038 http://www.locus.ufv.br/handle/123456789/19492 |
Data do documento: | 25-Nov-2015 |
Aparece nas coleções: | Artigos |
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artigo.pdf Until 2100-12-31 | Texto completo | 465,07 kB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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