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https://locus.ufv.br//handle/123456789/19064
Tipo: | Artigo |
Título: | Moderate continuous aerobic exercise training improves cardiomyocyte contractility in Β1 adrenergic receptor Knockout mice |
Autor(es): | Rodrigues, Aurora Corrêa Natali, Antônio José Cunha, Daise Nunes Queiroz da Costa, Alexandre Jayme Lopes Dantas Moura, Anselmo Gomes de Carneiro-Júnior, Miguel Araújo Félix, Leonardo Bonato Brum, Patrícia Chakur Prímola-Gomes, Thales Nicolau |
Abstract: | The lack of cardiac β1-adrenergic receptors (β1-AR) negatively affects the regulation of both cardiac inotropy and lusitropy, leading, in the long term, to heart failure (HF). Moderate-intensity aerobic exercise (MCAE) is recommended as an adjunctive therapy for patients with HF.We tested the effects of MCAE on the contractile properties of left ventricular (LV) myocytes from β1 adrenergic receptor knockout (β1ARKO) mice.Four- to five-month-old male wild type (WT) and β1ARKO mice were divided into groups: WT control (WTc) and trained (WTt); and β1ARKO control (β1ARKOc) and trained (β1ARKOt). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. P ≤ 0.05 was considered significant in all comparisons.The β1ARKO and exercised mice exhibited a higher (p < 0.05) running capacity than WT and sedentary ones, respectively. The β1ARKO mice showed higher body (BW), heart (HW) and left ventricle (LVW) weights, as well as the HW/BW and LVW/BW than WT mice. However, the MCAE did not affect these parameters. Left ventricular myocytes from β1ARKO mice showed increased (p < 0.05) amplitude and velocities of contraction and relaxation than those from WT. In addition, MCAE increased (p < 0.05) amplitude and velocities of contraction and relaxation in β1ARKO mice.MCAE improves myocyte contractility in the left ventricle of β1ARKO mice. This is evidence to support the therapeutic value of this type of exercise training in the treatment of heart diseases involving β1-AR desensitization or reduction. |
Palavras-chave: | Heart failure Exercise Myocardial contraction Myocytes Cardiac Adrenergic beta 1 receptor antagonists Mice |
Editor: | Arquivos Brasileiros de Cardiologia |
Tipo de Acesso: | Open Access |
URI: | http://publicacoes.cardiol.br/portal/abc/portugues/2018/v11003/treinamento-aerobico-continuo-de-intensidade-moderada-melhora-a-contratilidade-do-cardiomiocito-em-camundongos.asp http://www.locus.ufv.br/handle/123456789/19064 |
Data do documento: | 19-Fev-2018 |
Aparece nas coleções: | Artigos |
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