Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/19032
Tipo: Artigo
Título: Larvicidal activity of synthetic tropane alkaloids against Ascia monuste orseis (Lepidoptera: Pieridae)
Autor(es): Mairink, Simone Z
Barbosa, Luiz CA
Varejão, Eduardo VV
Farias, Elizeu S
Santos, Márcio LM
Picanço, Marcelo C
Abstract: Tropane alkaloids are known to play a role in plant defence. By blocking acetylcholine receptors, they exert insecticidal and deterrent effects against herbivore insects. Carbamates are an important class of chemical insecticides that also inhibit acetyl cholinesterase. The objective of this work was to synthesise a series of tropane alkaloids bearing a carbamate group, and to evaluate their effects against the pest Ascia monuste. The effects of the most active compounds were evaluated on the A. monuste predatorSolenopsis saevissima and on the pollinator Tetragonisca angustula. The synthesis of carbamate‐tropane alkaloids was accomplished in 4–5 steps from commercially available ketones. Results from bioassays showed that compounds 6a, 10a and 14a presented higher activities against second‐instar larvae of A. monuste, with LD50values of 1.01, 3.76 and 1.92 µg substance mg−1 insect, and TL50 values of 7.0, 15.0 and 5.0 h respectively. These compounds were also tested for their selectivity in favour of S. saevissima and T. angustula. Compound 6a, which showed the highest activity against A. monuste, also showed lower toxicity against S. saevissima. Tropane alkaloid derivatives bearing a carbamate group show potential for the development of novel insecticides against A. monuste. © 2017 Society of Chemical Industry
Palavras-chave: Insecticide activity
Tropane alkaloids
Carbamate
Ascia monuste
Solenopsis saevissima
Tetragonisca angustula
Editor: Pest Management Science
Tipo de Acesso: Open Access
URI: https://doi.org/10.1002/ps.4565
http://www.locus.ufv.br/handle/123456789/19032
Data do documento: 6-Mar-2017
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