Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/18057
Tipo: Artigo
Título: Synthesis and antifungal activity of halogenated aromatic bis-γ-lactones analogous to avenaciolide
Autor(es): Castelo-Branco, Pedro A.
Rubinger, Mayura M. M.
Alves, Leandro de C.
Liberto, Natalia A.
Nepel, Thayane C. M.
Catrinck, Mariana
Guilardi, Silvana
Silvério, Hudson A.
Zambolim, Laércio
Piló-Veloso, Dorila
F. Neto, Wilson P.
Abstract: Here we describe the total syntheses and characterization by elemental analyses, infrared and NMR spectroscopy of three new compounds analogous to avenaciolide, a bis-γ-lactone isolated from Aspergillus avenaceus that possesses antifungal activity, where the octyl group of the natural product was replaced by aromatic groups containing chlorine and fluorine atoms. The effects of the avenaciolide, the novel compounds and their synthetic precursors on mycelia development and conidia germination of Colletotrichum gloeosporioides and Fusarium solani were evaluated in vitro. The title compounds were almost as active as avenaciolide. The absolute structures of the chlorinated analogs were determined by X-ray diffraction analysis.
Palavras-chave: Avenaciolide analogues
Absolute structural determination
Antifungal activity
Editor: Química Nova
Tipo de Acesso: Open Access
URI: http://dx.doi.org/10.1590/S0100-40422012000500016
http://www.locus.ufv.br/handle/123456789/18057
Data do documento: 8-Nov-2011
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